How to reconstitute Cagrilintide
Cagrilintide is sold as a freeze-dried powder, most often in 5 mg, 10 mg vials. Add bacteriostatic water, let it dissolve without shaking, and the concentration is the vial amount divided by the water: 5 mg in 2 mL is 2.5 mg/mL. On a U-100 insulin syringe one unit is 0.01 mL, so each unit carries 25 mcg, and a 300 mcg dose is 12 units.
Not approved. Trials titrated from 0.3 mg to 2.4 mg once weekly. Nothing on this page is a dosing recommendation; the calculator converts a dose you already have into syringe units.
Cagrilintide doses in syringe units (5 mg vial, 2 mL water)
| Dose | Units | mL | Doses per vial |
|---|---|---|---|
| 300 mcg | 12 | 0.12 | 16 |
| 600 mcg | 24 | 0.24 | 8 |
| 1.2 mg | 48 | 0.48 | 4 |
| 2.4 mg | 96 | 0.96 | 2 |
Vial sizes at 300 mcg per dose
| Vial | Water | Concentration | Units per dose | Doses |
|---|---|---|---|---|
| 5 mg | 2 mL | 2.5 mg/mL | 12 | 16 |
| 10 mg | 2 mL | 5 mg/mL | 6 | 33 |
The dose column is in mg. Doubling the water halves the concentration and doubles the units per dose; the number of doses in the vial never changes. If a dose comes out under 5 units, use less water so it is easier to measure. If it exceeds the syringe, use more water or a bigger syringe.
Worked example
5 mg / 2 mL = 2.5 mg/mL = 2,500 mcg/mL. One unit = 0.01 mL = 25 mcg. 300 mcg / 25 mcg per unit = 12 units. The vial holds 5,000 / 300 = 16 doses, which at 1 per week is about 112 days.
See the general peptide calculator for the formulas, syringe sizes, and the common mg versus mcg mistakes.