How to reconstitute MOTS-c
MOTS-c is sold as a freeze-dried powder, most often in 5 mg, 10 mg, 40 mg vials. Add bacteriostatic water, let it dissolve without shaking, and the concentration is the vial amount divided by the water: 10 mg in 2 mL is 5 mg/mL. On a U-100 insulin syringe one unit is 0.01 mL, so each unit carries 50 mcg, and a 5 mg dose is 100 units.
Not approved for human use. Commonly cited: 5 to 10 mg two or three times a week. Nothing on this page is a dosing recommendation; the calculator converts a dose you already have into syringe units.
MOTS-c doses in syringe units (10 mg vial, 2 mL water)
| Dose | Units | mL | Doses per vial |
|---|---|---|---|
| 2.5 mg | 50 | 0.5 | 4 |
| 5 mg | 100 | 1 | 2 |
| 10 mg | 200 | 2 | 1 |
Vial sizes at 5 mg per dose
| Vial | Water | Concentration | Units per dose | Doses |
|---|---|---|---|---|
| 5 mg | 2 mL | 2.5 mg/mL | 200 | 1 |
| 10 mg | 2 mL | 5 mg/mL | 100 | 2 |
| 40 mg | 2 mL | 20 mg/mL | 25 | 8 |
The dose column is in mg. Doubling the water halves the concentration and doubles the units per dose; the number of doses in the vial never changes. If a dose comes out under 5 units, use less water so it is easier to measure. If it exceeds the syringe, use more water or a bigger syringe.
Worked example
10 mg / 2 mL = 5 mg/mL = 5,000 mcg/mL. One unit = 0.01 mL = 50 mcg. 5,000 mcg / 50 mcg per unit = 100 units. The vial holds 10,000 / 5,000 = 2 doses, which at 3 per week is about 5 days.
See the general peptide calculator for the formulas, syringe sizes, and the common mg versus mcg mistakes.